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After 8 weeks of treatment, 55 95 ci 32 , 77 of patients treated with entocort ec reached the endpoint cdai 150 , as compared to 68 95 ci 47 , 89 of patients treated with prednisolone.

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The incidence of signs/symptoms of hypercorticism as described above in long-term maintenance clinical trials was similar to that seen in the short-term treatment clinical trials.

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Monitor patients who are transferred from corticosteroid treatment with high systemic effects to corticosteroids with lower systemic availabilitysuch as ENTOCORT ECsince symptoms attributed to withdrawal of steroid therapyincluding those of acute adrenal axis suppression or benign intracranial hypertensionmay developAdrenocortical function monitoring may be required in these patients and the dose of corticosteroid treatment with high systemic effects should be reduced cautiously.

Consider reducing the dosage of ENTOCORT EC to 3 mg once daily for adult patients with moderate hepatic impairmentChild-Pugh Class BAvoid use in patients with severe hepatic impairmentChild-Pugh Class Csee WARNINGS AND PRECAUTIONSUse In Specific Populations

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