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SirolimusFluconazole increases plasma concentrations of sirolimus presumably by inhibiting the metabolism of sirolimus via CYP3A4 and P-glycoproteinThis combination may be used with a dose adjustment of sirolimus depending on the effect/concentration measurements.
Fluconazole inhibits CYP2C9CYP2C19and CYP3A4 isoenzymescoadministration with drugs that are substrates if these isoenzymes may be contraindicated or warrant dosage modifications.
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