Pharmacokinetics of danazol.
Information about Danazol.
Increase in red cell and platelet countReversible erythrocytosis or polycythaemia may be provokedEosinophilialeucopeniasplenic peliosis and thrombocytopenia have also been noted.
Administration of Danazol has been reported to cause exacerbation of the manifestations of acute intermittent porphyriaSee CONTRAINDICATIONS
In view of its pharmacologyknown interactions and side effectsparticular care should be observed when using danazol in patients with hepatic or renal diseasehypertension or other cardiovascular disease and in any state which may be exacerbated by fluid retention as well as in diabetes mellituspolycythaemiaepilepsylipoprotein disorderin those with a history of thrombosisand in those who have shown marked or persistent androgenic reaction to previous gonadal steroid therapyAdjustment in concomitant therapy may be called for particularly in patients with hypertensiondiabetes mellitus or epilepsy when introducing or discontinuing danazol as well as during Danazol treatment.
Until more is knowncaution is advised in the use of danazol in the presence of known or suspected malignant diseasesee also contraindicationsBefore treatment initiationthe presence of hormone-dependent carcinoma should be excluded at least by careful clinical examinationas well as if breast nodules persist or enlarge during danazol treatmentIn the event of virilisationDanazol should be withdrawnWhilst androgenic reactions will generally prove reversiblecontinued use of danazol in the face of evident virilisation is likely to cause irreversible androgenic effects.
4Porphyriadanazol can induce ALA synthetase activity and hence porphyrin metabolism.
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