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TABLE 3Treatment-Emergent Adverse EventsIncidence in Placebo-Controlled Clinical Trials

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Patients with major depressive disorderMDDboth adult and pediatricmay experience worsening of their depression and/or the emergence of suicidal ideation and behaviorsuicidalityor unusual changes in behaviorwhether or not they are taking antidepressant medicationsand this risk may persist until significant remission occursSuicide is a known risk of depression and certain other psychiatric disordersand these disorders themselves are the strongest predictors of suicideThere has been a long-standing concernhoweverthat antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment.

Because citalopram is extensively metabolizedexcretion of unchanged drug in urine is a minor route of eliminationUntil adequate numbers of patients with severe renal impairment have been evaluated during chronic treatment with Celexahoweverit should be used with caution in such patientssee DOSAGE AND ADMINISTRATION

If the decision has been made to discontinue treatmentmedication should be taperedas rapidly as is feasiblebut with recognition that abrupt discontinuation can be associated with certain symptomssee PRECAUTIONS and DOSAGE AND ADMINISTRATIONDiscontinuation of Treatment with Celexafor a description of the risks of discontinuation of Celexa

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The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongationBefore using ciprofloxacintell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac death

You should begin feeling better during the first few days of your treatment with ciprofloxacinIf your symptoms do not improve or if they get worsecall your doctorIf you are being treated for a urinary tract infectioncall your doctor if you develop fever or back pain during or after your treatmentThese symptoms may be signs that your infection is worsening.

Limitations-of-useReserve fluoroquinolones for patients who do not have other available treatment options for acute bacterial exacerbation of chronic bronchitis.

Ciprofloxacin is used to treat or prevent certain infections caused by bacteria such as pneumoniagonorrheaa sexually transmitted diseasetyphoid fevera serious infection that is common in developing countriesinfectious diarrheainfections that cause severe diarrheaand infections of the skinbonejointabdomenstomach areaand prostatemale reproductive glandCiprofloxacin is also used to treat or prevent plaguea serious infection that may be spread on purpose as part of a bioterror attackand inhalation anthraxa serious infection that may be spread by anthrax germs in the air on purpose as part of a bioterror attackCiprofloxacin may also be used to treat bronchitissinus infectionsor urinary tract infections but should not be used for bronchitis and sinus infectionsor certain types of urinary tract infections if there are other treatment optionsCiprofloxacin extended-releaselong-actingtablets are used to treat kidney and urinary tract infectionshoweversome types of urinary tract infections should only be treated with ciprofloxacin extended release tablets if no other treatment options are availableCiprofloxacin is in a class of antibiotics called fluoroquinolonesIt works by killing bacteria that cause infections.

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