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The Coxib and traditional NSAID TrialistsCollaboration meta-analysis of randomized controlled trials demonstrated an approximately twofold increase in hospitalizations for heart failure in COX-2 selective-treated patients and nonselective NSAID-treated patients compared to placebo-treated patientsIn a Danish National Registry study of patients with heart failureNSAID use increased the risk of MIhospitalization for heart failureand death.

An increase in the incidence of background findings of spermatocele with or without secondary changes such as epididymal hypospermia as well as minimal to slight dilation of the seminiferous tubules was seen in the juvenile ratThese reproductive findings while apparently treatment-related did not increase in incidence or severity with dose and may indicate an exacerbation of a spontaneous conditionSimilar reproductive findings were not observed in studies of juvenile or adult dogs or in adult rats treated with celecoxibThe clinical significance of this observation is unknown.

Do not use this medicine just before or after heart bypass surgerycoronary artery bypass graftor CABG

Severe skin reactionfeversore throatswelling in your face or tongueburning in your eyesskin pain followed by a red or purple skin rash that spreadsespecially in the face or upper bodyand causes blistering and peeling.

Carefully consider the potential benefits and risks of CELEBREX and other treatment options before deciding to use CELEBREXUse the lowest effective dosage for the shortest duration consistent with individual patient treatment goalssee WARNINGS AND PRECAUTIONS

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Every effort has been made to ensure that the information provided by Cerner MultumIncMultumis accurateup-to-dateand completebut no guarantee is made to that effectDrug information contained herein may be time sensitiveMultum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriateunless specifically indicated otherwiseMultum’s drug information does not endorse drugsdiagnose patients or recommend therapyMultum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement toand not a substitute forthe expertiseskillknowledge and judgment of healthcare practitionersThe absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safeeffective or appropriate for any given patientMultum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum providesThe information contained herein is not intended to cover all possible usesdirectionsprecautionswarningsdrug interactionsallergic reactionsor adverse effectsIf you have questions about the drugs you are takingcheck with your doctornurse or pharmacist.

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Rememberkeep this and all other medicines out of the reach of childrennever share your medicines with othersand use this medication only for the indication prescribed.

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