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Take Cozaar exactly as prescribed by your doctorFollow all directions on your prescription labelYour doctor may occasionally change your dose to make sure you get the best resultsDo not take this medicine in larger or smaller amounts or for longer than recommended.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.
Before taking losartantell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.
Numerous antihypertensive drugsfrom a variety of pharmacologic classes and with different mechanisms of actionhave been shown in randomized controlled trials to reduce cardiovascular morbidity and mortalityand it can be concluded that it is blood pressure reductionand not some other pharmacologic property of the drugsthat is largely responsible for those benefitsThe largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of strokebut reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.
Clinical trial data have shown that dual blockade of the renin-angiotensin-aldosterone systemRAASthrough the combined use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotensionhyperkalaemiaand decreased renal functionincluding acute renal failurecompared to the use of a single RAAS-acting agentsee sections 4.34.4and 5.1
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