A single-dose pharmacokinetic study demonstrated that the disposition of bupropion and its metabolites in elderly subjects was similar to that of younger subjects; however, another pharmacokinetic study, single and multiple dose, has suggested that the elderly are at increased risk for accumulation of bupropion and its metabolites see clinical pharmacology .

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additionally, in a study comparing 14-day dosing with wellbutrin xl tablets 300 mg once daily to the sustained-release formulation of bupropion at 150 mg 2 times daily, equivalence was demonstrated for peak plasma concentration and area under the curve for bupropion and the 3 metabolites.

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compared with a placebo control, bupropion approximately doubles smoking quit rates.

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bupropion is metabolised to its major active metabolite hydroxybupropion primarily by the cytochrome p450 cyp2b6 see section 5.

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according to the manufacturer of wellbutrin, drinking excessive amounts or abruptly withdrawing from alcohol after chronic use may increase the risk of seizure event in patients taking bupropion.
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In addition, since the compound includes bupropion, contrave comes using a boxed warning to alert health care professionals and patients for the increased risk of suicidal thoughts and behaviors related to antidepressant drugs.

Table 6 presents the incidence of body weight changes 5 lbs in the 3 sad trials using bupropion hcl extended-release.

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Dose at doses up to 300 mg day of the sustained-release formulation of bupropion wellbutrin sr , the incidence of seizure is approximately 0.

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Advise patients and caregivers that the patient using bupropion for smoking cessation should stop taking bupropion and contact a healthcare provider immediately if agitation, hostility, depressed mood, or changes in thinking or behavior that are not typical for the patient are observed, or if the patient develops suicidal ideation or suicidal behavior.

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meta-analyses show that quitting with bupropion has an odds ratio of 2.

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No statistically significant differences in the pharmacokinetics of bupropion were observed in patients with mild to moderate hepatic cirrhosis compared with healthy volunteers, but bupropion plasma levels showed a higher variability between individual patients.

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Therefore, the potential exists for drug interactions between bupropion and drugs that are inhibitors or inducers of cyp2b6.

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The latest smoking cessation trial focused on young smokers compared varenicline and bupropion xl.

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