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Continue Clozaril treatmentsample blood twice weekly until counts stabilise or increase.

Clozaril can have long lasting effects on your bodyYou may need frequent medical tests for a short time after you stop using this medicine.

Clozaril may enhance the central effects of CNS depressants such as narcoticsantihistamines and benzodiazepinesParticular caution is advised when Clozaril therapy is initiated in patients who are receiving a benzodiazepine or any other psychotropic agentThese patients may have an increased risk of circulatory collapsewhichon rare occasionscan be profound and may lead to cardiac and/or respiratory arrestIt is not clear whether cardiac or respiratory collapse can be prevented by dose adjustment.

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Metabolic syndrome can also be a side effect of antipsychotic medications, especially the drug clozapine clozaril .

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Clozaril is indicated in treatment-resistant schizophrenic patients and in schizophrenia patients who have severeuntreatable neurological adverse reactions to other antipsychotic agentsincluding atypical antipsychotics.

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Concomitant use of lithium or other CNS-active agents may increase the risk of development of neuroleptic malignant syndromeNMS

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Take Clozaril exactly as prescribed by your doctorFollow all directions on your prescription labelYour doctor may occasionally change your doseDo not take this medicine in larger or smaller amounts or for longer than recommended.

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Clozaril can cause severe dizzinessslow heartbeatsfaintingor seizuresDo not take more of this medicine than recommendedBe careful if you drive or do anything that requires you to be alertAvoid getting up too fast from a sitting or lying positionor you may feel dizzyDizziness or severe drowsiness can cause fallsfracturesor other injuries.

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instruct patients to inform their clinicians that they are taking clozaril before any new drug see warnings and precautions and drug interactions .