Nexium may affect how other medicines work and other medicines may affect how nexium works.
Information about Nexium.
NEXIUM Delayed-Release Capsules40 mgare opaquehard gelatinamethyst colored capsules with three radial bars in yellow on the cap and NEXIUM 40 mg in yellow on the bodyThey are supplied as follows:
Empty the contents of a 2.5 mg or 5 mg packet into a container containing 5 mL of waterFor the 10 mg20 mgand 40 mg strengthsthe contents of a packet should be emptied into a container containing 15 mL of waterStirLeave 2 to 3 minutes to thickenStir and drink within 30 minutesIf any medicine remains after drinkingadd more waterstirand drink immediatelyIn cases where there is a need to use two packetsthey may be mixed in a similar way by adding twice the required amount of water or follow the mixing instructions provided by your pharmacist or doctor.
The effect of NEXIUM on intragastric pH was determined in patients with symptomatic gastroesophageal reflux disease in two separate studiesIn the first study of 36 patientsNEXIUM 40 mg and 20 mg capsules were administered over 5 daysThe results are shown in the Table 3:
NEXIUM is contraindicated in patients with known hypersensitivity to substituted benzimidazoles or to any component of the formulationHypersensitivity reactions may include anaphylaxisanaphylactic shockangioedemabronchospasmacute interstitial nephritisand urticariasee ADVERSE REACTIONS
A preand postnatal developmental toxicity study in rats with additional endpoints to evaluate bone development was performed with esomeprazole magnesium at oral doses of 14 to 280 mg/kg/dayabout 3.4 to 68 times an oral human dose of 40 mg on a body surface area basisNeonatal/early postnatalbirth to weaningsurvival was decreased at doses equal to or greater than 138 mg/kg/dayabout 34 times an oral human dose of 40 mg on a body surface area basisBody weight and body weight gain were reduced and neurobehavioral or general developmental delays in the immediate post-weaning timeframe were evident at doses equal to or greater than 69 mg/kg/dayabout 17 times an oral human dose of 40 mg on a body surface area basisIn additiondecreased femur lengthwidth and thickness of cortical bonedecreased thickness of the tibial growth plate and minimal to mild bone marrow hypocellularity were noted at doses equal to or greater than 14 mg/kg/dayabout 3.4 times an oral human dose of 40 mg on a body surface area basisPhyseal dysplasia in the femur was observed in offspring of rats treated with oral doses of esomeprazole magnesium at doses equal to or greater than 138 mg/kg/dayabout 34 times an oral human dose of 40 mg on a body surface area basis
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nexium and prilosec both are approved for treating non-cancerous or benign gastric ulcers.
