Interaction studies have shown that pioglitazone has no relevant effect on either the pharmacokinetics or pharmacodynamics of digoxin, warfarin, phenprocoumon and metformin.

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Loss of appetitenauseaand vomiting Changes in visionsuch as flashes or flickering of lightsensitivity to lightseeing things larger or smaller than they areblurringcolor changesyellow or greenand seeing halos or borders on objects Drowsiness and fatigue Headache Confusion Depression Muscle weakness Irregular heartbeat or slow heart rate.

Digoxin may be taken with or without foodDigoxin primarily is eliminated by the kidneysthereforethe dose of digoxin should be reduced in patients with kidney dysfunctionDigoxin blood levels are used for adjusting doses in order to avoid toxicityThe usual starting dose is 0.0625-0.25 mg daily depending on age and kidney functionThe dose may be increased every two weeks to achieve the desired responseThe usual maintenance dose is 0.125 to 0.5 mg per day.

Digoxin is usually taken once a dayTry to take this drug at the same time every dayFollow the label directions on how often to take itThe time allowed between doses and how long you need to take it will depend on your conditionYou may have to take this drug for a long timepossibly for the rest of your life.

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major in a pharmacokinetic study of 11 healthy men, increases in digoxin auc 86 , volume of distribution, and half-life were seen, while renal and non-renal clearance decreased, when coadministered with ritonavir.