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The effects of this drug on human sperm are unknownHoweverbased on animal cell studiesthe manufacturer recommends waiting for a period of time after completing griseofulvin treatment before trying to father a childDiscuss the risks and benefits with your doctorand ask how long to wait after your last dose before trying to father a child.

Serious skin reactions can occur with this medicineStop using this medicine and check with your doctor right away if you or your child have blisteringpeelingor loosening of the skinred skin lesionssevere acne or skin rashsores or ulcers on the skinor fever or chills while you are using this medicine.

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Before using this medicationtell your doctor or pharmacist your medical historyespecially oflupus.

There are no adequate studies in women for determining infant risk when using this medication during breastfeedingWeigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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The use of TRICOR should be avoided in patients who have severe renal impairmentsee CONTRAINDICATIONSDose reduction is required in patients with mild to moderate renal impairmentsee DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGYMonitoring renal function in patients with renal impairment is recommended.

Markedly elevated levels of serum triglyceridese.g2,000 mg/dLmay increase the risk of developing pancreatitisThe effect of fenofibrate therapy on reducing this risk has not been adequately studied.

Baseline and regular periodic monitoring of liver functionincluding serum ALTSGPTshould be performed for the duration of therapy with TRICORand therapy discontinued if enzyme levels persist above three times the normal limit.

In a 21-month study in CF-1 micefenofibrate 1045and 200 mg/kg/dayapproximately 0.21and 3 times the MRHD on the basis of mg/m 2 surface areasignificantly increased the liver carcinomas in both sexes at 3 times the MRHDIn a second 18-month study at 1060and 200 mg/kg/dayfenofibrate significantly increased the liver carcinomas in male mice and liver adenomas in female mice at 3 times the MRHD.

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