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Deaths due to drug accumulation overdose have been reported in patients with renal impairment, who were prescribed higher than recommended doses of amantadine hydrochloride for their level of renal function see dosage and administration ; dosage for impaired renal function and overdosage .
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Against type b influenza viruses, amantadine is not effective.
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Rare instances of reversible elevation of liver enzymes have been reported in patients receiving amantadine hydrochloride, though a specific relationship between the drug and such changes has not been established.
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the nasal vaccine may not be as effective if you receive it while you are taking amantadine.
