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A dose of 50 mg once a day will produce adequate clinical blockade of the actions of parenterally administered opioidsAs with many non-agonist treatments for addictionREVIA is of proven value only when given as part of a comprehensive plan of management that includes some measure to ensure the patient takes the medication.
REVIA is a pure opioid antagonistIt does not lead to physical or psychological dependenceTolerance to the opioid antagonist effect is not known to occur.
This could result in potentially life-threatening opioid intoxicationrespiratory compromise or arrestcirculatory collapseetcif the patient uses previously tolerated doses of opioidsCases of opioid overdose with fatal outcomes have been reported in patients after discontinuing treatment.
There is limited clinical experience with REVIA overdosage in humansIn one studysubjects who received 800 mg daily REVIA for up to one week showed no evidence of toxicity.
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