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Symptoms of an allergic reactione.gitchinessrashrednesssymptoms of high blood calcium bone pain decreased appetite drowsiness dry mouth fatigue fever frequent urination headache itchiness metallic taste in the mouth muscle pain stomach ache or cramps thirst trouble sleeping weakness weight loss symptoms of irregular heartbeate.gshortness of breathrapid or pounding heartbeatunusual sweating)

Patients with vitamin D-resistant ricketsfamilial hypophosphataemiashould continue their oral phosphate therapyHoweverpossible stimulation of intestinal phosphate absorption by calcitriol should be taken into account since this effect may modify the requirement for phosphate supplements.

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Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.

Rocaltrolcalcitriolshould not be given to patients with hypercalcemia or evidence of vitamin D toxicityUse of Rocaltrolcalcitriolin patients with known hypersensitivity to Rocaltrolcalcitriolor drugs of the same classor any of the inactive ingredients is contraindicated.

Supravalvular aortic stenosis has been produced in foetuses by near-fatal oral doses of vitamin D in pregnant rabbitsThere is no evidence to suggest that vitamin D is teratogenic in humans even at very high dosesRocaltrol should be used during pregnancy only if the benefits outweigh the potential risk to the foetus.

If the patient is switched from a long acting vitamin D preparatione.gergocalciferolvitamin D 2or colecalciferolto calcitriolit may take several months for the ergocalciferol level in the blood to return to the baseline valuethereby increasing the risk of hypercalcaemiasee section 4.9

Do not dispose of medications in wastewatere.gdown the sink or in the toiletor in household garbageAsk your pharmacist how to dispose of medications that are no longer needed or have expired.

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Since calcitriol is the most potent active metabolite of vitamin D 3pharmacological doses of vitamin D and its derivatives should be withheld during treatment with Rocaltrolcalcitriolto avoid possible additive effects and hypercalcemiasee WARNINGS

Clinical experience with Rocaltrol in elderly patients indicates that the dosage recommended for use in younger adults may be given without apparent ill-consequence.

Immobilized patientsegthose who have undergone surgeryare particularly exposed to the risk of hypercalcemia.

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since blood level of calcitriol will be reduced, higher doses of rocaltrol calcitriol may be necessary if these drugs are administered simultaneously.