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John PCunhaDOis a U.Sboard-certified Emergency Medicine PhysicianDrCunha’s educational background includes a BS in Biology from Rutgersthe State University of New Jerseyand a DO from the Kansas City University of Medicine and Biosciences in Kansas CityMOHe completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in NewarkNew Jersey.

SKELAXINmetaxaloneis indicated as an adjunct to restphysical therapyand other measures for the relief of discomforts associated with acutepainful musculoskeletal conditionsThe mode of action of this drug has not been clearly identifiedbut may be related to its sedative propertiesMetaxalone does not directly relax tense skeletal muscles in man.

Renal or hepatic impairmentmonitor LFTsElderlyPregnancynursing mothersnot recommended.

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Although plasma protein binding and absolute bioavailability of metaxalone are not knownthe apparent volume of distributionV/F.

The bioavailability of metaxalone under fasted and fed conditions in three groups of healthy volunteers of varying age is shown in Table 2.

You should not use Skelaxin if you have anemialow red blood cellsor severe kidney or liver diseaseYou may need a dose adjustment or special tests to safely take Skelaxin.

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222An overdose of metaxalone can be fatal.

Skelaxin is only part of a complete treatment program that may also include restphysical therapyor other pain relief measuresFollow your doctor’s instructions.

Table 2MeanCVPharmacokinetic Parameters Following Single Administration of Two 400 mg SKELAXIN Tablets800 mgunder Fasted and Fed Conditions.

Taking SKELAXIN with food may enhance general CNS depressionelderly patients may be especially susceptible to this CNS effectSee CLINICAL PHARMACOLOGYPharmacokinetics and PATIENT INFORMATION

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