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The following serious adverse reactions are discussed in greater detail in other sections of the label:

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leafletDo not use CRESTOR for a condition for which it was not prescribedDo not give CRESTOR to other peopleeven if they have the same medical condition you haveIt may harm them.

The following adverse reactions have been identified during postapproval use of CRESTORarthralgiafatal and non-fatal hepatic failurehepatitisjaundicethrombocytopeniadepressionsleep disordersincluding insomnia and nightmaresperipheral neuropathy and gynecomastiaBecause these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Rosuvastatin was not mutagenic or clastogenic with or without metabolic activation in the Ames test with Salmonella typhimurium and Escherichia colithe mouse lymphoma assayand the chromosomal aberration assay in Chinese hamster lung cellsRosuvastatin was negative in the in vivo mouse micronucleus test.

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As with any antihypertensive agentsexcessive blood pressure decrease in patients with ischaemic cardiovascular and cerebrovascular disease could result in a myocardial infarction or stroke.

Although losartan may be used to prevent kidney problems or treat people who have kidney problemsit may also rarely cause serious kidney problems or make them worseYour doctor will check your kidney function while you are taking losartanTell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.

Dizziness or lightheadedness may occur as your body adjusts to the medicationIf any of these effects persist or worsentell your doctor or pharmacist promptly.

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Allopurinol zyloprim aminosalicylates such as mesalamine apriso, asacol, pentasa, others , olsalazine dipentum , and sulfasalazine azulfidine blood thinners such as warfarin coumadin .

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Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery EliquisXareltowarfarinLovenoxapixabanenoxaparinMore.

The anticoagulant effect of COUMADIN persists beyond 24 hoursIf a patient misses a dose of COUMADIN at the intended time of daythe patient should take the dose as soon as possible on the same dayThe patient should not double the dose the next day to make up for a missed dose.

Examples of drugs known to increase the risk of bleeding are presented in Table 3Because bleeding risk is increased when these drugs are used concomitantly with warfarinclosely monitor patients receiving any such drug with warfarin.

Take Coumadin exactly as prescribed by your doctorFollow all directions on your prescription labelYour doctor may occasionally change your doseDo not take warfarin in larger or smaller amounts or for longer than your doctor tells you to.

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conservatively, 15 to 20 percent of people with diabetes of medicare age also take coumadin, tim says.