These results were in the same tumor model used to justify the study of tamoxifen for the prevention of breast cancer.
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in the nsabp p-1 trial, few grade 3 to 4 changes in liver function sgot, sgpt, bilirubin, alkaline phosphatase were observed 10 on placebo and 6 on tamoxifen .
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this evidence that tamoxifen causes vte does not significantly alter the benefit-risk ratio for tamoxifen when it is used to treat breast cancer.
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