In a trial comparing chronic dosing with wellbutrin sr 150 mg twice daily to bupropion immediate-release formulation 100 mg 3 times daily, the steady state cmax for bupropion after wellbutrin sr administration was approximately 85 of those achieved after bupropion immediate-release formulation administration.

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Seizure risk is dose-relatedcan minimize risk by limiting daily dose to 522 mg and gradually increasing dosediscontinue permanently in patients who experience seizures.

Risk of mydriasismay trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomyuse caution.

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In short-term studiesantidepressants increased t suicidal thinking and behavior in childrenadolescentsand young adultsyounger than 24 yearstaking antidepressants for major depressive disorders and other psychiatric illnessesthis increase was not seen in patients older than 24 years Slight decrease in suicidal thinking was seen in adults older than 65 years In children and young adultsrisks must be weighed against the benefits of taking antidepressants Patients should be monitored closely for changes in behaviorclinical worseningand suicidal tendenciesthis should be done during initial 1-2 months of therapy and dosage adjustments The patient’s family should communicate any abrupt changes in behavior to the healthcare provider Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapythis drug is not approved for use in pediatric patients.

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Dose at doses up to 300 mg day of the sustained-release formulation of bupropion wellbutrin sr , the incidence of seizure is approximately 0.

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