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Signs of peritoneal irritation following gastrointestinal perforation in patients receiving corticosteroids may be minimal or absent.

Literature reports suggest apparent association between use of corticosteroids and left ventricular free wall rupture after recent myocardial infarctiontherapy with corticosteroids should be used with great caution in these patients.

This drug may make you dizzyAlcohol or marijuana can make you more dizzyDo not driveuse machineryor do anything that needs alertness until you can do it safelyLimit alcoholic beveragesTalk to your doctor if you are using marijuana.

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If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivityclose observation is necessary as reactivation of the disease may occurDuring prolonged corticosteroid therapythese patients should receive chemoprophylaxis.

Corticosteroids have been shown to be teratogenic in many species when given in doses equivalent to the human doseAnimal studies in which corticosteroids have been given to pregnant miceratsand rabbits have yielded an increased incidence of cleft palate in the offspringThere are no adequate and well-controlled studies in pregnant womenCorticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetusInfants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism.

Congestive heart failure in susceptible patientsfluid retentionhypokalemic alkalosispotassium losssodium retention.

Patients should also be advised that if they are exposedmedical advice should be sought without delay.

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