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A drug trade names calan and isoptin used as an oral or parenteral calcium blocker in cases of hypertension or congestive heart failure or angina or migraine.

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It is not known whether the use of verapamil during labor or delivery has immediate or delayed adverse effects on the fetusor whether it prolongs the duration of labor or increases the need for forceps delivery or other obstetric interventionSuch adverse experiences have not been reported in the literaturedespite a long history of use of verapamil in Europe in the treatment of cardiac side effects of beta-adrenergic agonist agents used to treat premature labor.

In overdosetablets of Isoptin SR have occasionally been reported to form concretions within the stomach or intestinesThese concretions have not been visible on plain radiographs of the abdomenand no medical means of gastrointestinal emptying is of proven efficacy in removing themEndoscopy might reasonably be considered in cases of massive overdose when symptoms are unusually prolonged.

In overdosetablets of Isoptin SR have occasionally been reported to form concretions within the stomach or intestinesThese concretions have not been visible on plain radiographs of the abdomenand no medical means of gastrointestinal emptying is of proven efficacy in removing themEndoscopy might reasonably be considered in cases of massive overdose when symptoms are unusually prolonged.

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amiodarone cordarone , verapamil calan verelan, isoptin , danazol, niacin niacor, niaspan, slo-niacin , gemfibrozil lopid and fenofibrate tricor warfarin coumadin , and digoxin lanoxin .

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Immediately telephone your doctor or the poisons information centre telephone 13 11 26 for advice, or go to accident and emergency at your nearest hospital, if you think that you or anyone else may have taken too much isoptin.

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Postmarketing reportsAngina pectoris/chest painAV dissociationECG abnormalclaudicationhypertensionmyocardial infarctionsinus arrest with asystoledecreased myocardial contractilitycardiogenic shockbradyarrhythmia in atrial fibrillationvasculitiserythromelalgiaRef]

Cardiovascularangina pectorisatrioventricular dissociationchest painclaudicationmyocardial infarctionpalpitationspurpuravasculitissyncope.

NitratesVerapamil has been given concomitantly with shortand long-acting nitrates without any undesirable drug interactionsThe pharmacologic profile of both drugs and the clinical experience suggest beneficial interactions.

Postmarketing reportsEcchymosisbruisingalopecia/hair losshyperkeratosismaculesStevens-Johnson syndromehyperhidrosis/sweatingerythema multiformeQuincke’s edema/angioneurotic edemaRef]

Do not stop taking this medication without consulting your doctorSome conditions may become worse when this drug is suddenly stoppedYour dose may need to be gradually decreased.

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treat all verapamil overdoses as serious and maintain observation for at least 48 hours especially isoptin sr verapamil hydrochloride preferably under continuous hospital care.
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