A weight gain can be a common side effect of the selective serotonin reuptake inhibitors ssris , the class of drugs that includes lexapro escitalopram .

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Combined administration of racemic citalopram40 mg/day for 14 daysand carbamazepinetitrated to 400 mg/day for 35 daysdid not significantly affect the pharmacokinetics of carbamazepinea CYP3A4 substrateAlthough trough citalopram plasma levels were unaffectedgiven the enzyme-inducing properties of carbamazepinethe possibility that carbamazepine might increase the clearance of escitalopram should be considered if the two drugs are coadministered.

Escitalopram is metabolized to S-DCT and S-didemethylcitalopramS-DDCTIn humansunchanged escitalopram is the predominant compound in plasmaAt steady statethe concentration of the escitalopram metabolite S-DCT in plasma is approximately one-third that of escitalopramThe level of S-DDCT was not detectable in most subjectsIn vitro studies show that escitalopram is at least 7 and 27 times more potent than S-DCT and S-DDCTrespectivelyin the inhibition of serotonin reuptakesuggesting that the metabolites of escitalopram do not contribute significantly to the antidepressant actions of escitalopramS-DCT and S-DDCT also have no or very low affinity for serotonergic5-HT 1-7or other receptors including alphaand beta-adrenergicdopamineD 1-5histamineH 1-3muscarinicM 1-5and benzodiazepine receptorsS-DCT and S-DDCT also do not bind to various ion channels including NaKCl and Cachannels.

Lexapro has not been systematically evaluated in patients with a recent history of myocardial infarction or unstable heart diseasePatients with these diagnoses were generally excluded from clinical studies during the product’s premarketing testing.

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any other antidepressants such as amitriptyline elavil, vanatrip, limbitrol , escitalopram lexapro , imipramine tofranil , sertraline zoloft , and others, alprazolam xanax , clopidogrel plavix , clozapine clozaril, fazaclo , flecainide tambocor , haloperidol haldol , nebivolol bystolic , vinblastine velban , a blood thinner such as warfarin coumadin, jantoven , migraine headache medicine such as almotriptan axert , frovatriptan frova , sumatriptan imitrex, treximet , naratriptan amerge , rizatriptan maxalt , or zolmitriptan zomig , or seizure medication such as phenytoin dilantin or carbamazepine carbatrol, equetro, tegretol .