Hypersensitivity to dipyridamole.
Information about Dipyridamole.
Some side effects can be seriousIf you experience any of the following symptomscall your doctor immediately:
If someone has overdosed and has serious symptoms such as passing out or trouble breathingcall 911Otherwisecall a poison control center right awayUS residents can call their local poison control center at 1-800-222-1222Canada residents can call a provincial poison control centerSymptoms of overdose may includeflushingsweatingrestlessnessweaknessdizzinessfast heartbeat.
In studies in which dipyridamole was administered in the feed to miceup to 111 weeks in males and femalesand ratsup to 128 weeks in males and up to 142 weeks in femalesthere was no evidence of drug-related carcinogenesisThe highest dose administered in these studies75 mg/kg/daywason a mg/m 2 basisabout equivalent to the maximum recommended daily human oral doseMRHDin mice and about twice the MRHD in ratsMutagenicity tests of dipyridamole with bacterial and mammalian cell systems were negativeThere was no evidence of impaired fertility when dipyridamole was administered to male and female rats at oral doses up to 500 mg/kg/dayabout 12 times the MRHD on a mg/m 2 basisA significant reduction in number of corpora lutea with consequent reduction in implantations and live fetuses washoweverobserved at 1250 mg/kgmore than 30 times the MRHD on a mg/m 2 basis
Dipyridamole inhibits phosphodiesterasePDEin various tissuesWhile the inhibition of cAMP-PDE is weaktherapeutic levels of dipyridamole inhibit cyclic-35guanosine monophosphate-PDEcGMP-PDEthereby augmenting the increase in cGMP produced by EDRFendothelium-derived relaxing factornow identified as nitric oxide
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