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Pioglitazone in fixed combination with immediate-release metformin hydrochloride actoplus met is administered once or twice daily with meals to reduce the gi effects of the metformin hydrochloride component.

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Macula dma has bn potd in postmakting xpinc in diabtic patints whw taking pioglitazon anoth thiazolidindion. Som patints psntd with blud vision dcasd visual acuity, but oths w diagnosd on outin ophthalmologic xamination.

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Bladd canc Pioglitazon may b linkd tan incasd isk bladd canc Dnot pscib patints with activ bladd canc Consid bnit:isk atibpscibing in patints with a histoy bladd canc Instuct patints tcontact thi physician i signs bladd canc obsvd at initiating thapy (g, blood d colod uin, nw wosning uinay ugncy, pain on uination) Postat canc 7/22/2015: Compad with nonus, pioglitazon us was associatd with incasd isk postat canc (453.3 vs. 449.3 p 100,000 pson-yas) [JAMA 2015 July 21;314(3):265-277] Pancatic canc 7/22/2015: Compad with nonus, pioglitazon us was associatd with incasd isk pancatic canc (81.1 vs. 48.4 p 100,000 pson-yas) [JAMA 2015 July 21;314(3):265-277]

Th onst lactic acidosis otn is subtl, and accompanid only by nonspciic symptoms such as malais, myalgias, spiatoy distss, incasing somnolnc, and nonspciic abdominal distss. Th may b associatd hypothmia, hypotnsion, and sistant badyahythmias with mmakd acidosis. Patints should b ducatd tpomptly pot ths symptoms should thy occu. I psnt, ACTOPLUS MT should b withdawn until lactic acidosis is uld out. Sum lctolyts, ktons, blood glucos, blood pH, lactat lvls, and blood mtomin lvls may b usul. Onc a patint is stabilizd on any dos lvl mtomin, gastointstinal symptoms, which a common duing initiation thapy, a unlikly tcu. Lat occunc gastointstinal symptoms could b du tlactic acidosis oth sious disas.

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In these studies, 904 patients were randomized to placebo, keppra 1000 mg, keppra 2000 mg, or keppra 3000 mg day.

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Keppra can be used on its own in patients from 16 years of age with newly diagnosed epilepsyto treat partial-onset seizuresfitswith or without secondary generalisationThis is a type of epilepsy where too much electrical activity in one side of the brain causes symptoms such as suddenjerky movements of one part of the bodydistorted hearingsense of smell or visionnumbnessor a sudden sense of fearSecondary generalisation occurs when the overactivity later reaches the whole brain.

Keppra injection is for intravenous use only as an alternative for patients when oral administration is temporarily not feasible.

There was about a 22increase of apparent total body clearance of levetiracetam when it was co-administered with enzyme-inducing AEDsDose adjustment is not recommendedLevetiracetam had no effect on plasma concentrations of carbamazepinevalproatetopiramateor lamotrigine.

There have been isolated reports of decreased levetiracetam efficacy when the osmotic laxative macrogol has been concomitantly administered with oral levetiracetamThereforemacrogol should not be taken orally for one hour before and for one hour after taking levetiracetam.

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patients, their caregivers, and families should be counseled that aeds, including keppra, may increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior, or thoughts about self-harm.