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Do not change brands of isosorbide mononitrate without the approval of your doctor.

Concomitant administration with guanylate stimulator riociguatmay cause hypotension)

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If possibletry to rest or stay seated when you use this medicationIsosorbide mononitrate can cause dizziness or fainting.

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Before taking Hyzaartell your doctor if you haveor have ever hadKidney disease Problems with urination Liver disease Congestive heart failure Glaucoma Asthma Gout High or low levels of potassium in your blood Lupus Diabetes Bouts of dehydration Allergies to medicinesespecially sulfa drugs or penicillin)

RarelyHyzaar can cause a condition that leads to kidney failureCall your doctor immediately if you experience any of the following symptomsUnexplained muscle paintendernessor weaknessespecially if accompanied by feverUnusual tiredness Dark-colored urine.

Before using this medicationtell your doctor or pharmacist your medical historyespecially ofgoutkidney diseaseliver diseaselupussevere loss of body water and mineralsdehydration

Every effort has been made to ensure that the information provided by on this page is accurateup-to-dateand completebut no guarantee is made to that effectDrug information contained herein may be time sensitiveThe information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriateunless specifically indicated otherwiseNeither Everyday Health nor its licensors endorse drugsdiagnose patients or recommend therapyThe drug information above is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement toand not a substitute forthe expertiseskillknowledge and judgment of healthcare practitionersThe absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safeeffective or appropriate for any given patientNeither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information providedThe information contained herein is not intended to cover all possible usesdirectionsprecautionswarningsdrug interactionsallergic reactionsor adverse effectsIf you have any questions about the drugs you are takingcheck with your doctornurse or pharmacist.

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Alfuzosin uroxatral doxazosin cardura prazosin minipress silodosin rapaflo tamsulosin flomax terazosin hytrin .

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The dose of terazosin should be adjusted according to the patient’s responseThe following is a guide to administration:

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The symptoms associated with BPH are related to bladder outlet obstructionwhich is comprised of two underlying componentsa static component and a dynamic componentThe static component is a consequence of an increase in prostate sizeOver timethe prostate will continue to enlargeHoweverclinical studies have demonstrated that the size of the prostate does not correlate with the severity of BPH symptoms or the degree of urinary obstruction1 The dynamic component is a function of an increase in smooth muscle tone in the prostate and bladder neckleading to constriction of the bladder outletSmooth muscle tone is mediated by sympathetic nervous stimulation of alpha-l adrenoceptorswhich are abundant in the prostateprostatic capsule and bladder neckThe reduction in symptoms and improvement in urine flow rates following administration of terazosin is related to relaxation of smooth muscle produced by blockade of alpha-l adrenoceptors in the bladder neck and prostateBecause there are relatively few alpha-l adrenoceptors in the bladder bodyterazosin is able to reduce the bladder outlet obstruction without affecting bladder contractility.

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