Metabolism of colchicine in vivo has not been fully investigated in humans niel and scherrmann, 2006 , but the in vitro experiments have demonstrated that colchicine undergoes same oxidative demethylation in both human and rat liver microsomes tateishi et al.
Information about Colchicine.
Toxic manifestations associated with colchicine include myelosuppressiondisseminated intravascular coagulationand injury to cells in the renalhepaticcirculatoryand central nervous systemThese most often occur with excessive accumulation or overdosagesee OVERDOSE
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
About all of your medical conditions if you have kidney or liver problems if you are pregnant or plan to become pregnantIt is not known if colchicine capsules can harm your unborn babyTalk to your healthcare provider if you are pregnant or plan to become pregnantif you are breastfeeding or plan to breastfeedColchicine can pass into your breast milk and may harm your babyTalk to your healthcare provider about the best way to feed your baby if you take colchicine capsules.
If co-administration of colchicine capsules and a CYP3A4 inhibitor is necessarythe dose of colchicine capsules should be adjusted by either reducing the daily dose or reducing the dose frequencyand the patient should be monitored carefully for colchicine toxicitySee CLINICAL PHARMACOLOGY
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