Synthroid and an ab-rated generic l-t 4 are not bioequivalent for patients with severe hypothyroidism due to ch, probably because of diminished thyroid reserve.

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Applies to levothyroxinecompounding powderinjectable powder for injectionintravenous powder for injectionoral capsuleoral solutionoral tablet.

Thyroid hormones cross the placental barrier to some extent as evidenced by levels in cord blood of athyreotic fetuses being approximately one-third maternal levelsTransfer of thyroid hormone from the mother to the fetushowevermay not be adequate to prevent in utero hypothyroidism.

The goal of replacement therapy is to achieve and maintain a clinical and biochemical euthyroid stateThe goal of suppressive therapy is to inhibit growth and/or function of abnormal thyroid tissueThe dose of SYNTHROID that is adequate to achieve these goals depends on a variety of factors including the patient’s agebody weightcardiovascular statusconcomitant medical conditionsincluding pregnancyconcomitant medicationsand the specific nature of the condition being treatedsee WARNINGS and PRECAUTIONSHencethe following recommendations serve only as dosing guidelinesDosing must be individualized and adjustments made based on periodic assessment of the patient’s clinical response and laboratory parameterssee PRECAUTIONSLaboratory Tests

Applies to levothyroxinecompounding powderinjectable powder for injectionintravenous powder for injectionoral capsuleoral solutionoral tablet.

Levothyroxine doses are based on weight in childrenYour dose needs may change if you gain or lose weight.

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it should be noted that the fda response to knoll s request, while implying that synthroid had production problems, did not label synthroid as a dangerous drug in which case it would have been removed from the market , but simply required knoll to undergo the same nda process as its competitors.