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In some individuals the use of opioid antagonists has been associated with a change in baseline levels of some hypothalamicpituitaryadrenalor gonadal hormonesThe clinical significance of such changes is not fully understood.
Cases of hepatitis and clinically significant liver dysfunction were observed in association with REVIA exposure during the clinical development program and in the postmarketing periodTransientasymptomatic hepatic transaminase elevations were also observed in the clinical trials and postmarketing periodWhen patients presented with elevated transaminasesthere were often other potential causative or contributory etiologies identifiedincluding pre-existing alcoholic liver diseasehepatitis B and/or C infectionand concomitant usage of other potentially hepatotoxic drugsAlthough clinically significant liver dysfunction is not typically recognized as a manifestation of opioid withdrawalopioid withdrawal that is precipitated abruptly may lead to systemic sequelaeincluding acute liver injury.
REVIA does not interfere with thin-layergas-liquidand high pressure liquid chromatographic methods which may be used for the separation and detection of morphinemethadone or quinine in the urineREVIA may or may not interfere with enzymatic methods for the detection of opioids depending on the specificity of the testPlease consult the test manufacturer for specific details.
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the arrows indicate the administration of naltrexone n 16 or vehicle saline; n 13 .