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The Coxib and traditional NSAID TrialistsCollaboration meta-analysis of randomized controlled trials demonstrated an approximately twofold increase in hospitalizations for heart failure in COX-2 selective-treated patients and nonselective NSAID-treated patients compared to placebo-treated patientsIn a Danish National Registry study of patients with heart failureNSAID use increased the risk of MIhospitalization for heart failureand death.

An increase in the incidence of background findings of spermatocele with or without secondary changes such as epididymal hypospermia as well as minimal to slight dilation of the seminiferous tubules was seen in the juvenile ratThese reproductive findings while apparently treatment-related did not increase in incidence or severity with dose and may indicate an exacerbation of a spontaneous conditionSimilar reproductive findings were not observed in studies of juvenile or adult dogs or in adult rats treated with celecoxibThe clinical significance of this observation is unknown.

Do not use this medicine just before or after heart bypass surgerycoronary artery bypass graftor CABG

Severe skin reactionfeversore throatswelling in your face or tongueburning in your eyesskin pain followed by a red or purple skin rash that spreadsespecially in the face or upper bodyand causes blistering and peeling.

Carefully consider the potential benefits and risks of CELEBREX and other treatment options before deciding to use CELEBREXUse the lowest effective dosage for the shortest duration consistent with individual patient treatment goalssee WARNINGS AND PRECAUTIONS

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Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practiceThe adverse reaction information from clinical trials doeshoweverprovide a basis for identifying the adverse events that appear to be related to drug use and for approximating rates.

Liver and biliaryHepatic enzyme increasedincluding SGOT increasedSGPT increased)

Celebrex may also cause stomach or intestinal bleedingwhich can be fatalThese conditions can occur without warning while you are using Celebrexespecially in older adultsYou should not take this medicine if you already have bleeding in your stomach or intestines.

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I do find it odd that if my wife had arthritis she could probably easily convince a doctor to give her celebrex but for a much more dangerous condition they say no.

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Table 5Complicated and Symptomatic Ulcer Rates in Patients Taking CELEBREX 400 mg Twice DailyKaplan-Meier Rates at 9 monthsBased on Risk Factors.

CardiovascularAggravated hypertensionangina pectoriscoronary artery disordermyocardial infarction.

Known hypersensitivitye.ganaphylactic reactions and serious skin reactionsto celecoxibany components of the drug productsee WARNINGS AND PRECAUTIONSHistory of asthmaurticariaor other allergic-type reactions after taking aspirin or other NSAIDsSeveresometimes fatalanaphylactic reactions to NSAIDshave been reported in such patientssee WARNINGS AND PRECAUTIONSIn the setting of coronary artery bypass graftCABGsurgerysee WARNINGS AND PRECAUTIONSIn patients who have demonstrated allergic-type reactions to sulfonamides.

The incidence of endoscopic ulcers was studied in two 12-weekplacebo-controlled studies in 2157 OA and RA patients in whom baseline endoscopies revealed no ulcersThere was no dose relationship for the incidence of gastroduodenal ulcers and the dose of CELEBREX50 mg to 400 mg twice dailyThe incidence for naproxen 500 mg twice daily was 16.2 and 17.6in the two studiesfor placebo was 2.0 and 2.3and for all doses of CELEBREX the incidence ranged between 2.75.9There have been no largeclinical outcome studies to compare clinically relevant GI outcomes with CELEBREX and naproxen.

Take Celebrex exactly as prescribed by your doctorFollow all directions on your prescription labelDo not take this medicine in larger amounts or for longer than recommendedUse the lowest dose that is effective in treating your condition.

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