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Potential for radiation recall when used in conjunction with radiation therapy.

Cyclophosphamide is available in generic formand you need a prescription to obtain it.

Further dilute the reconstituted Cyclophosphamide solution to a minimum concentration of 2 mg per mL with any of the following diluents:

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Add the diluent to the vial and shake it vigorously to dissolveIf the powder fails to dissolve immediately and completelyit is advisable to allow the vial to stand for a few minutesUse the quantity of diluent shown below to constitute the product:

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Cyclophosphamide increases the occurrence of heart failure that is caused by doxorubicinAdriamycinincreases the action of blood thinners such as warfarinCoumadinand decreases the effectiveness of quinolone antibiotics ciprofloxacinCiproCipro XRProquin XR

CongenitalFamilial and Geneticintra-uterine deathfetal malformationfetal growth retardationfetal toxicityincluding myelosuppressiongastroenteritis

Amenorrhea associated with decreased estrogen and increased gonadotropin secretion develops in a significant proportion of women treated with cyclophosphamideAffected patients generally resume regular menses within a few months after cessation of therapyGirls treated with cyclophosphamide during prepubescence generally develop secondary sexual characteristics normally and have regular mensesOvarian fibrosis with apparently complete loss of germ cells after prolonged cyclophosphamide treatment in late prepubescence has been reportedGirls treated with cyclophosphamide during prepubescence subsequently have conceived.

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DUse in LIFE-THREATENING emergencies when no safer drug availablePositive evidence of human fetal risk.

For which conditions is this drug approvedCyclophosphamide is commonly used for the treatment of several cancersincluding lymphomasmultiple myelomaleukemiasadvanced mycosis fungoidesadvanced neuroblastomaovarian cancerretinoblastoma and breast cancerIt is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDAPatients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.

Cyclophosphamide has been reported to potentiate doxorubicin-induced cardiotoxicity.

Many other regimens of intravenous and oral cyclophosphamide have been reportedDosages must be adjusted in accord with evidence of antitumor activity and/or leukopeniaThe total leukocyte count is a goodobjective guide for regulating dosage.

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