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Estrogens should be used with caution in individuals with severe hypocalcemia.

ESTRACE should not be used inwomen with undiagnosed abnormal genital bleedingknownsuspected or history of breast cancerknown or suspected estrogen-dependent neoplasiaactive deep vein thrombosispulmonary embolism or a history of these conditionsactive arterial thromboembolic diseasefor examplestrokemyocardial infarctionor a history of these conditionsknown anaphylactic reaction or angioedema to ESTRACEliver dysfunction or diseasethrombophilic disordersknown or suspected pregnancy.

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Estrogen administration should be initiated at the lowest dose approved for the indication and then guided by clinical response rather than by serum hormone levelse.gestradiolFSHSee DOSAGE AND ADMINISTRATION section

Most prospective studies of efficacy for this indication have been carried out in white menopausal womenwithout stratification by other risk factorsand tend to show a universally salutary effect on bone.

Please see full Prescribing InformationincludingBoxed Warning and Patient Information.

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Safety and effectiveness in pediatric patients have not been establishedLarge and repeated doses of estrogen over an extended period of time have been shown to accelerate epiphyseal closureresulting in short adult stature if treatment is initiated before the completion of physiologic puberty in normally developing childrenIn patients in whom bone growth is not completeperiodic monitoring of bone maturation and effects on epiphyseal centers is recommended.

Some mixtures of medications can lead to serious and even fatal consequences.

Safety and effectiveness in pediatric patients have not been establishedLarge and repeated doses of estrogen over an extended period of time have been shown to accelerate epiphyseal closureresulting in short adult stature if treatment is initiated before the completion of physiologic puberty in normally developing childrenIn patients in whom bone growth is not completeperiodic monitoring of bone maturation and effects on epiphyseal centers is recommended.

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the function of estrace is to increase the level of estradiol.