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Analyses were also performed in each study to examine the effect of NEURONTIN on preventing secondarily generalized tonic-clonic seizuresPatients who experienced a secondarily generalized tonic-clonic seizure in either the baseline or in the treatment period in all three placebo-controlled studies were included in these analysesThere were several response ratio comparisons that showed a statistically significant advantage for NEURONTIN compared to placebo and favorable trends for almost all comparisons.

Avoid taking an antacid within 2 hours before or after you take NeurontinAntacids can make it harder for your body to absorb gabapentin.

Acute oral overdoses of NEURONTIN up to 49 grams have been reportedIn these casesdouble visionslurred speechdrowsinesslethargyand diarrhea were observedAll patients recovered with supportive careComaresolving with dialysishas been reported in patients with chronic renal failure who were treated with NEURONTIN.

Neurontingabapentinis an anti-epileptic drugalso called an anticonvulsantIt affects chemicals and nerves in the body that are involved in the cause of seizures and some types of pain.

The most common adverse reactions with NEURONTIN in combination with other antiepileptic drugs in patients12 years of agenot seen at an equivalent frequency among placebo-treated patientswere somnolencedizzinessataxiafatigueand nystagmus.

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Drug Reaction With Eosinophilia And Systemic SymptomsDRESSMultiorgan Hypersensitivity.

Do not take NEURONTIN if you are allergic to gabapentin or any of the other ingredients in NEURONTINSee the end of this Medication Guide for a complete list of ingredients in NEURONTIN.

Studies designed to investigate the mechanism of gabapentin-induced pancreatic carcinogenesis in rats indicate that gabapentin stimulates DNA synthesis in rat pancreatic acinar cells in vitro andthusmay be acting as a tumor promoter by enhancing mitogenic activityIt is not known whether gabapentin has the ability to increase cell proliferation in other cell types or in other speciesincluding humans.

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NEURONTIN can cause anaphylaxis and angioedema after the first dose or at any time during treatmentSigns and symptoms in reported cases have included difficulty breathingswelling of the lipsthroatand tongueand hypotension requiring emergency treatmentPatients should be instructed to discontinue NEURONTIN and seek immediate medical care should they experience signs or symptoms of anaphylaxis or angioedema.

Prior to initiation of treatment with NEURONTINinstruct patients that a rash or other signs or symptoms of hypersensitivitysuch as fever or lymphadenopathymay herald a serious medical event and that the patient should report any such occurrence to a physician immediatelysee WARNINGS AND PRECAUTIONS

Tell your healthcare provider about all the medicines you takeincluding prescription and over-thecounter medicinesvitaminsand herbal supplements.

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