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In neonatal/juvenile animalsrats and dogstoxicities were similar to those observed in adult animalsincluding gastric alterationsdecreases in red cell massincreases in lipidsenzyme induction and hepatocellular hypertrophyAn increased incidence of eosinophilic chief cells in adult and neonatal/juvenile ratsand atrophy of chief cells in adult rats and in neonatal/juvenile dogswas observed in the fundic mucosa of stomachs in repeated-dose studiesFull to partial recovery of these effects were noted in animals of both age groups following a recovery period.
Applies to pantoprazoleintravenous powder for injectionoral delayed release tabletoral granule enteric coated.
If you are giving the granules through a tube into the stomachnasogastric or gastric tubeask your health care professional for detailed instructions on how to properly mix and give it.
The following adverse reactions have been identified during postapproval use of Protonix and Protonix I.VBecause these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
After oral administration there was a modest increase in the AUC and C max of pantoprazole in women compared to menHoweverweight-normalized clearance values are similar in women and men.
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