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Most COPD patints, th mdicin in Atovnt HA stats impoving lung unction within about 15 minuts. Atovnt HA taks about th tims long than albutol tstat woking. this ason, it is not commndd us as a scu inhal.
Ipatopium bomid is a quatnay ammonium compound with anticholingic (paasympatholytic) poptis. In nonclinical studis, it appas tinhibit vagally mdiatd lxs by antagonising th action actylcholin, th tansmitt agnt lasd om th vagus nv. Anticholingics pvnt th incas in intacllula concntation Ca++ which is causd by intaction actylcholin with th muscainic cpton bonchial smooth muscl. Ca++ las is mdiatd by th scond mssng systm consisting IP3 (inositol tiphosphat) and DAG (diacylglycol).
(2) As with oth inhalation thapy, inhalation inducd bonchoconstiction may occu with an immdiat incas in whzing at dosing. This should b tatd staight away with a ast acting inhald bonchodilato. ATOVNT should b discontinud immdiatly, th patint assssd and, i ncssay, altativ tatmnt institutd.
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