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An increase to the maintenance dose of 24 mg/day should be considered on an individual basis after appropriate assessment including evaluation of clinical benefit and tolerability.

Reminyl tablets contain lactose monohydratePatients with rare hereditary problems of galactose intolerancethe Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Data from clinical trials in patients indicate that the plasma concentrations of galantamine in patients with Alzheimer’s disease are 30-40higher than in healthy young subjectsBased upon the population pharmacokinetic analysisclearance in female subjects is 20lower as compared to malesNo major effects of age per se or race are found on the galantamine clearanceThe galantamine clearance in poor metabolisers of CYP2D6 is about 25lower than in extensive metabolisersbut no bimodality in the population is observedThereforethe metabolic status of the patient is not considered to be of clinical relevance in the overall population.

Multiple metabolic pathways and renal excretion are involved in the elimination of galantamineThe possibility of clinically relevant interactions is lowHoweverthe occurrence of significant interactions may be clinically relevant in individual cases.

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