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In a healthy volunteer cross-over studyN=10co-administration of a single 20 mg dose of simvastatin at the end of a 14 day regimen with 120 mg BID diltiazem SR resulted in a 5-fold increase in mean simvastatin AUC versus simvastatin aloneSubjects with increased average steady-state exposures of diltiazem showed a greater fold increase in simvastatin exposureComputer-based simulations showed that at a daily dose of 480 mg of diltiazeman 8-to 9-fold mean increase in simvastatin AUC can be expectedIf co-administration of simvastatin with diltiazem is requiredlimit the daily doses of simvastatin to 10 mg and diltiazem to 240 mg.
Due to the potential for additive effectscaution and careful titration are warranted in patients receiving CARDIZEM concomitantly with any agents known to affect cardiac contractility and/or conductionsee WARNINGS
Some medicines may interfere with Cardizem CD capsules or Cardizem tabletsThese include:
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