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Reglan Injection is indicated for the prophylaxis of postoperative nausea and vomiting in those circumstances where nasogastric suction is undesirable.

Hypotensionhypertensionsupraventricular tachycardiabradycardiafluid retentionacute congestive heart failure and possible atrioventricularAVblocksee CONTRAINDICATIONS and PRECAUTIONS

The risk of developing parkinsonian-like side effects increases with ascending doseGeriatric patients should receive the lowest dose of Reglan Injection that is effectiveIf parkinsonian-like symptoms develop in a geriatric patient receiving Reglan InjectionReglan Injection should generally be discontinued before initiating any specific anti-parkinsonian agentssee WARNINGS

A few cases of rashurticariaor bronchospasmespecially in patients with a history of asthmaRarelyangioneurotic edemaincluding glossal or laryngeal edema.

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A few cases of rashurticariaor bronchospasmespecially in patients with a history of asthmaRarelyangioneurotic edemaincluding glossal or laryngeal edema.

Care should be exercised in administering metoclopramide to neonates since prolonged clearance may produce excessive serum concentrationssee CLINICAL PHARMACOLOGYPharmacokineticsIn additionneonates have reduced levels of NADH-cytochrome b 5 reductase whichin combination with the aforementioned pharmacokinetic factorsmake neonates more susceptible to methemoglobinemiasee OVERDOSE

Transient flushing of the face and upper bodywithout alterations in vital signsfollowing high doses intravenously.

Experience with esophageal erosions and ulcerations is limitedbut healing has thus far been documented in one controlled trial using q.i.dtherapy at 15 mg/doseand this regimen should be used when lesions are presentso long as it is toleratedsee ADVERSE REACTIONSBecause of the poor correlation between symptoms and endoscopic appearance of the esophagustherapy directed at esophageal lesions is best guided by endoscopic evaluation.

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Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastricbiliaryor pancreatic secretionsIts mode of action is unclearIt seems to sensitize tissues to the action of acetylcholineThe effect of metoclopramide on motility is not dependent on intact vagal innervationbut it can be abolished by anticholinergic drugs.

A few cases of neutropenialeukopeniaor agranulocytosisgenerally without clear-cut relationship to metoclopramideMethemoglobinemia in adults and especially with overdosage in neonatessee OVERDOSAGESulfhemoglobinemia in adults.

Symptoms of overdosage may include drowsinessdisorientation and extrapyramidal reactionsAnticholinergic or antiparkinson drugs or antihistamines with anticholinergic properties may be helpful in controlling the extrapyramidal reactionsSymptoms are self-limiting and usually disappear within 24 hours.

Intravenous infusions should be made slowly over a period of not less than 15 minutes30 minutes before beginning cancer chemotherapy and repeated every 2 hours for two dosesthen every 3 hours for three doses.

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