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Patients with pre-existing liver dysfunction including chronic active hepatitis have an increased frequency of liver function abnormalities during combination antiretroviral therapy and should be monitored according to standard practiceIf there is evidence of worsening liver disease in such patientsinterruption or discontinuation of treatment must be considered.
No clinical data availableDue to the metabolic pathway of raltegravir no interaction is expected.
To support the use of the prolonged-release tabletsthe company conducted studies to show that the immediateand prolonged-release tablets both had adequate drug levelsand the same effect on the viral load in the bodyStudies were also done to show successful switching from immediate-release tabletstwice daily to prolonged-release tabletsonce daily.
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