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Table 1Adult Recommended Dosage Regimen for Prevention of Nausea and Vomiting.

Otherless than 2Anaphylaxisbronchospasmtachycardiaanginahypokalemiaelectrocardiographic alterationsvascular occlusive eventsand grand mal seizuresExcept for bronchospasm and anaphylaxisthe relationship to ZOFRAN is unclear.

Ondansetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancerchemotherapy or radiation

Although no pharmacokinetic drug interaction between ondansetron and tramadol has been observeddata from 2 small trials indicate that when used togetherZOFRAN may increase patient-controlled administration of tramadolMonitor patients to ensure adequate pain control when ondansetron is administered with tramadol.

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Recognizing a new market of patients for its drugGlaxoSmithKline advertised to doctors and mothers-to-be looking for relief from these symptoms.

Although ZofranZuplenz and the generic ondansetron are FDA-approved only for use in treating nausea and vomiting after chemotherapy or radiotherapy or after surgerymany doctors prescribe them for off-label usesincluding treatment of morning sickness in expectant mothers.

It is not known whether ondansetron is present in human milkThere are no data on the effects of ZOFRAN on the breastfed infant or the effects on milk productionHoweverit has been demonstrated that ondansetron is present in the milk of rats.

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Symptoms associated with serotonin syndrome may include the following combination of signs and symptomsmental status changese.gagitationhallucinationsdeliriumand comaautonomic instabilitye.gtachycardialabile blood pressuredizzinessdiaphoresisflushinghyperthermianeuromuscular symptomse.gtremorrigiditymyoclonushyperreflexiaincoordinationseizureswith or without gastrointestinal symptomse.gnauseavomitingdiarrheaPatients should be monitored for the emergence of serotonin syndromeespecially with concomitant use of ZOFRAN and other serotonergic drugsIf symptoms of serotonin syndrome occurdiscontinue ZOFRAN and initiate supportive treatmentPatients should be informed of the increased risk of serotonin syndromeespecially if ZOFRAN is used concomitantly with other serotonergic drugssee DRUG INTERACTIONSOVERDOSE

Take exactly as prescribed by your doctorDo not take in larger or smaller amounts or for longer than recommendedFollow the directions on your prescription label.

FDA staff assessed ondansetron and other antiemetic use among pregnant women delivering live births between 2001 and 2015In over 2.3 million pregnanciesthe prevalence of ondansetron was 15.2 percentaccording to the FDAUse was highest in the first trimester.

Daily fractions to abdomenAdminister 8 mg PO 1-2 hr before radiotherapyadminister subsequent doses every 8 hr after first dose each day radiotherapy is given.

Zofran and other 5-GT3 receptor antagonists are considered antiemetic agentsThese are any drugs that prevent vomiting or nausea including over-the-counter antihistaminesBenadrylDramamineor bismuth subsalicylatePepto-BismolKaopectate

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