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Other important adverse events reported with ZOLOFT overdosesingle or multiple drugsinclude bradycardiabundle branch blockcomaconvulsionsdeliriumhallucinationshypertensionhypotensionmanic reactionpancreatitisQTc-interval prolongationTorsade de Pointesserotonin syndromestuporand syncopeSee CLINICAL PHARMACOLOGY

Zoloftsertralineis an SSRIselective serotonin reuptake inhibitorsantidepressant prescribed for the treatment of depressionobsessive compulsive disorderOCDpanic disorderposttraumatic stress disorderPTSDsocial anxiety disorderand premenstrual dysphoric disorderPMDDZoloft is available as a generic drugCommon side effects of Zoloft includesleepiness drowsiness tired feeling nervousness sleep problemsinsomniadizziness nausea skin rash headache diarrhea constipation upset stomach stomach pain dry mouth changes in appetite abnormal ejaculation impotence decreased sex drive difficulty having an orgasm dry mouthand weight loss.

This medication may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be alert.

Birth defects and fetal harm are possible when Zoloft is taken during pregnancybut the risk is very lowThe drug may be transferred via breast milkThereforetalk to your doctor about the risks and benefits if you are pregnantplanning to become pregnantor are nursing before you take Zoloft.

Neonates exposed to ZOLOFT and other SSRIs or SNRIs late in the third trimester have developed complications requiring prolonged hospitalizationrespiratory supportand tube feedingThese findings are based on post-marketing reportsSuch complications can arise immediately upon deliveryReported clinical findings have included respiratory distresscyanosisapneaseizurestemperature instabilityfeeding difficultyvomitinghypoglycemiahypotoniahypertoniahyperreflexiatremorjitterinessirritabilityand constant cryingThese features are consistent with either a direct toxic effect of SSRIs and SNRIs orpossiblya drug discontinuation syndromeIn some casesthe clinical picture was consistent with serotonin syndromeSee WARNINGS AND PRECAUTIONS

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False-positive urine immunoassay screening tests for benzodiazepines have been reported in patients taking ZOLOFTThis finding is due to lack of specificity of the screening testsFalse-positive test results may be expected for several days following discontinuation of ZOLOFTConfirmatory testssuch as gas chromatography/mass spectrometrywill help distinguish ZOLOFT from benzodiazepinesSee DRUG INTERACTIONS

Other important adverse events reported with ZOLOFT overdosesingle or multiple drugsinclude bradycardiabundle branch blockcomaconvulsionsdeliriumhallucinationshypertensionhypotensionmanic reactionpancreatitisQTc-interval prolongationTorsade de Pointesserotonin syndromestuporand syncopeSee CLINICAL PHARMACOLOGY

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Do not take these drugs with sertralineWhen they are used with sertralinethey can cause dangerous effects in your bodyThese drugs include:

In a study assessing disposition of ZOLOFT100 mgon the second of 8 days of cimetidine administration800 mg dailythere were increases in ZOLOFT mean AUC50Cmax24and half-life26compared to the placebo groupSee DRUG INTERACTIONS

Tell your doctor right away if you become pregnant while taking this medicationSertaline may cause heart defects or serious lung problems in a newborn if you take the medication during pregnancyHoweveryou may have a relapse of depression if you stop taking your antidepressantDo not start or stop taking sertraline during pregnancy without your doctor’s advice.

Advise patients and their caregivers to observe for signs of activation of mania/hypomania and instruct them to report such symptoms to the healthcare providerSee WARNINGS AND PRECAUTIONS

Advise the patient to read the FDA-approved patient labelingMedication Guide

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