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Symptoms associated with serotonin syndrome may include the following combination of signs and symptomsmental status changese.gagitationhallucinationsdeliriumand comaautonomic instabilitye.gtachycardialabile blood pressuredizzinessdiaphoresisflushinghyperthermianeuromuscular symptomse.gtremorrigiditymyoclonushyperreflexiaincoordinationseizureswith or without gastrointestinal symptomse.gnauseavomitingdiarrheaPatients should be monitored for the emergence of serotonin syndromeespecially with concomitant use of ZOFRAN and other serotonergic drugsIf symptoms of serotonin syndrome occurdiscontinue ZOFRAN and initiate supportive treatmentPatients should be informed of the increased risk of serotonin syndromeespecially if ZOFRAN is used concomitantly with other serotonergic drugssee DRUG INTERACTIONSOVERDOSE
Take exactly as prescribed by your doctorDo not take in larger or smaller amounts or for longer than recommendedFollow the directions on your prescription label.
FDA staff assessed ondansetron and other antiemetic use among pregnant women delivering live births between 2001 and 2015In over 2.3 million pregnanciesthe prevalence of ondansetron was 15.2 percentaccording to the FDAUse was highest in the first trimester.
Daily fractions to abdomenAdminister 8 mg PO 1-2 hr before radiotherapyadminister subsequent doses every 8 hr after first dose each day radiotherapy is given.
Zofran and other 5-GT3 receptor antagonists are considered antiemetic agentsThese are any drugs that prevent vomiting or nausea including over-the-counter antihistaminesBenadrylDramamineor bismuth subsalicylatePepto-BismolKaopectate
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