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neonates exposed to paroxetine hydrochloride controlled-release tablets and other ssris or serotonin and norepinephrine reuptake inhibitors snris , late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding.
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use of amitriptyline may also be contraindicated with the selective serotonin reuptake inhinitor such as sertraline, fluvoxamine, paroxetine and fluoxetine.
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the possibility of a pathological fracture, that is, a fracture produced by minimal trauma in a patient with decreased bone mineral density, should be considered in patients treated with paroxetine who present with unexplained bone pain, point tenderness, swelling, or bruising.
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significant weight loss may be an undesirable result of treatment with paroxetine for some patients but, on average, patients in controlled trials with paxil cr or the immediate-release formulation, had minimal weight loss about 1 pound .
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the most commonly observed adverse events associated with the use of paroxetine incidence of 5 or greater and incidence for paroxetine tablets at least twice that for placebo, derived from table 3 were sweating, nausea, dry mouth, constipation, decreased appetite, somnolence, tremor, libido decreased, yawn, abnormal ejaculation, female genital disorders, and impotence.
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