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Table 9Established and Other Potentially Significant Drug InteractionsAlteration in Dose or Regimen May Be Recommended Based on Drug Interaction Studies or Predicted InteractionSee also CLINICAL PHARMACOLOGY for magnitude of interactionWARNINGS and DOSAGE AND ADMINISTRATION

See your doctor regularly so that he/she can monitor your healthContinue to practise safer sex and take other precautions so as not to pass HIV on to other people.

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Indirect hyperbilirubinemia has occurred frequently during treatment with CRIXIVAN and has infrequently been associated with increases in serum transaminasessee also ADVERSE REACTIONSClinical Trials and Post-Marketing ExperienceIt is not known whether CRIXIVAN will exacerbate the physiologic hyperbilirubinemia seen in neonatesSee Pregnancy

Urogenital Systemnephrolithiasis/urolithiasisin some cases resulting in renal insufficiency or acute renal failurepyelonephritis with or without bacteremiasee WARNINGSinterstitial nephritis sometimes with indinavir crystal depositsin some patientsthe interstitial nephritis did not resolve following discontinuation of CRIXIVANrenal insufficiencyrenal failureleukocyturiasee PRECAUTIONScrystalluriadysuria.

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Propranolol may also be used for purposes not listed in this medication guide.

You should not use Inderal if you have asthmavery slow heart beatsor a serious heart condition such assick sinus syndromeorAV blockunless you have a pacemaker

Atrial and ventricular arrhythmiassee literatureTachyarrhythmia due to digitalis intoxicationIn stabilized patients after MIto reduce mortality and risk of reinfarction.

Atrial and ventricular arrhythmiassee literatureTachyarrhythmia due to digitalis intoxicationIn stabilized patients after MIto reduce mortality and risk of reinfarction.

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It is important that you take this medication regularly as prescribeddo not stop taking it and do not take more or less of the drug than is prescribed.

Imuran therapy should not be initiated in patients who may be pregnantor who are likely to become pregnant without careful assessment of risk versus benefitsee Special Warnings and Precautions for UsePregnancy and Lactation

The principal and potentially serious toxic effects of IMURAN are hematologic and gastrointestinalThe risks of secondary infection and malignancy are also significantsee WARNINGSThe frequency and severity of adverse reactions depend on the dose and duration of IMURAN as well as on the patient’s underlying disease or concomitant therapiesThe incidence of hematologic toxicities and neoplasia encountered in groups of renal homograft recipients is significantly higher than that in studies employing IMURAN for rheumatoid arthritisThe relative incidences in clinical studies are summarized below:

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