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1 mg at bedtime is the starting dose for all patientsand this dose should not be exceeded as an initial dosePatients should be closely followed during initial administration in order to minimize the risk of severe hypotensive response.

Figure 3Mean Change in Peak Flow Rate from Baseline Long-termOpen-labelNon-placebo Controlled StudyN494)

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Food does not influence the absorption of triamterene or hydrochlorothiazide from triamterene and hydrochlorothiazide tablets.

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Taking these drugs with hydrochlorothiazide can cause further electrolyte lossespecially potassiumThis can lead to medical problemsExamples of these drugs include:

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This medicine is sometimes prescribed for other usesask your doctor or pharmacist for more information.

Calcium excretion is decreased by thiazidesand pathologic changes in the parathyroid glandswith hypercalcemia and hypophosphatemiahave been observed in a few patients on prolonged thiazide therapy.

CorticosteroidACTHintensified electrolyte depletionparticularly hypokalemia.

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What to do if you miss a doseTake your dose as soon as you rememberBut if you remember just a few hours before your next scheduled dosetake only one doseNever try to catch up by taking two doses at onceThis could result in dangerous side effects.

Resistant chronic myeloid leukemiaLocally advanced squamous cell carcinomas of the head and neckexcluding the lipin combination with chemoradiation.

A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.

There are no data that support specific guidance for dosage adjustment in patients with hepatic impairmentClose monitoring of hematologic parameters is advised in these patients.

Following oral administration of HYDREAhydroxyurea reaches peak plasma concentrations in 1 to 4 hoursMean peak plasma concentrations and AUCs increase more than proportionally with increase of dose.

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