Laxatives or methylnaltrexone for the management of constipation in palliative care patients.
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Confusion hallucinationsseeing things or hearing voices that do not existblurred vision severe vomiting and/or diarrhea.
Blurred vision or eye problemsfast heartbeatmood changeshallucinationsseeing or hearing thingsconfusionthoughts of hurting yourselfnauseastomach painlow feverloss of appetitedark urineclay-colored stoolsjaundiceyellowing of the skin or eyesear.
The mechanism of action of REVIA in alcoholism is not understoodhoweverinvolvement of the endogenous opioid system is suggested by preclinical dataREVIAan opioid receptor antagonistcompetitively binds to such receptors and may block the effects of endogenous opioidsOpioid antagonists have been shown to reduce alcohol consumption by animalsand REVIA has been shown to reduce alcohol consumption in clinical studies.
Patients with addictive disordersespecially opioid addictionare at risk for multiple numerous adverse events and abnormal laboratory findingsincluding liver function abnormalitiesData from both controlled and observational studies suggest that these abnormalitiesother than the dose-related hepatotoxicity described aboveare not related to the use of REVIA.
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naltrexone should not be used in children and adolescents under 18 years of age, since clinical data in this age-group are lacking.