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After oral administration of famciclovirthe bioavailability of penciclovir is about 70Food delays absorption but does not affect the final plasma drug concentrationPeak concentrations of drug after intravenous administration of 10 mg/kg are approximately 6-fold higher than those attained after oral doses of 250 mgDrug half-life is 2.5 hoursalmost 75of administered drug is recovered unchanged in the urineand dose reduction is recommended for those with compromised renal functionA 12-hour dosing interval is recommended for those with CrCl between 30 and 50 mL/min per 1.73 m 2and a 24-hour interval for those with CrCl 2135 Measurable penciclovir concentrations are not detectable in plasma or urine after topical administration of penciclovir creamFamciclovir pharmacokinetics have been assessed in a single-dose pediatric study of infants 1 to 12 months of age who were given famciclovir sprinkles orally136 Infants under 6 months of age had substantially lower systemic exposure compared with 6to 12-month-olds.
ProbenecidBenemidmay reduce the kidney’s removal of famciclovir leading to higher concentrations of famciclovir in the bloodThis may lead to side effects from famciclovir.
Famciclovir is used for people with strong immune systemsas well as people who are infected with HIVIt should not be used to treat:
Do not have certain immunizations/vaccinationssuch as vaccines against the varicella viruswithout the consent of your doctor.
Jay WMarksMDis a board-certified internist and gastroenterologistHe graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
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