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In a 2-year carcinogenicity study in Sprague Dawley ratsmometasone furoate demonstrated no statistically significant increase in the incidence of tumors at inhalation doses up to 67 mcg/kgapproximately 1 and 2 times the maximum recommended daily intranasal doseMRDIDin adults400 mcgand children100 mcgrespectivelyon a mcg/m 2 basisIn a 19-month carcinogenicity study in Swiss CD-1 micemometasone furoate demonstrated no statistically significant increase in the incidence of tumors at inhalation doses up to 160 mcg/kgapproximately 2 times the MRDID in adults and childrenrespectivelyon a mcg/m 2 basis
Following the use of intranasal corticosteroidsinstances of increased intraocular pressure have been reportedsee section 4.8
NASONEX Nasal Spray 50 mcg is indicated for the prophylaxis of the nasal symptoms of seasonal allergic rhinitis in adult and adolescent patients 12 years and older.
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