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Ketoconazole has been shown to be teratogenicsyndactylia and oligodactyliain the rat when given orally in the diet at 80 mg/kg/daya dose 10 times the maximum recommended human oral doseHoweverthese effects may be related to maternal toxicitywhich was seen at this and higher dose levels.
Co-administration of ketoconazole with potent CYP3A4 enzyme inducers is not recommended.
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progesterone should be used with caution with ketoconazole nizoral , clarithromycin biaxin , and erythromycin ery-tab because they slow the breakdown of progesterone and increase its levels in the body.