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In a 21-month carcinogenicity study in micethere was an increased incidence of ovarian tumors in female animals given 9 to 242 mg/kgwhich included benign and malignant tumors of granulosa/theca cell origin and benign tumors of epithelial cell originSystemic exposureAUCof raloxifene in this group was 0.3 to 34 times that in postmenopausal women administered a 60 mg doseThere was also an increased incidence of testicular interstitial cell tumors and prostatic adenomas and adenocarcinomas in male mice given 41 or 210 mg/kg4.7 or 24 times the AUC in humansand prostatic leiomyoblastoma in male mice given 210 mg/kg.
Other side effectsdrug interactionsdosageand pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.
These results are consistent with data from human studies of radiocalcium kinetics and markers of bone metabolismand are consistent with the action of EVISTA as a skeletal antiresorptive agent.
Discontinuation from the study was required when excessive bone loss or multiple incident vertebral fractures occurredSuch discontinuation was statistically significantly more frequent in the placebo group3.7than in the EVISTA group1.1
A broken bone is a fractureThere are different types of fracturessuch ascompressedopenstressgreenstick.
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evista medication can be taken with or without food.