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Claithomycin : Atovastatin AUC was signiicantly incasd with concomitant administation atovastatin 80 mg with claithomycin (500 mg twic daily) compad tthat atovastatin alon. Tho, in patints taking claithomycin, caution should b usd whn th dos atovastatin xcds 20 mg.

Gmibozil: Du tan incasd isk myopathy/habdomyolysis whn HMG-CoA ductas inhibitos a co-administd with gmibozil, concomitant administation ATOLIP CV with gmibozil should b avoidd.

Non-stoidal Anti-inlammatoy Agnts (NSAIDs): Co-administation ATOLIP CV and NSAIDs incass th isk gastointstinal blding and hnc should b co-administd with caution. Although aspiin did not modiy th clopidogl-mdiatd inhibition ADP-inducd platlt agggation, clopidogl potntiatd th ct aspiin on collagn-inducd platlt agggation. Howv, concomitant administation 500 mg aspiin twic a day on day did not signiicantly incas th polongation blding tim inducd by clopidogl intak. A phamacodynamic intaction btwn ATOLIP CV and aspiin is possibl, lading tincasd isk blding. Tho, concomitant us should b undtakn with caution. Howv, clopidogl and aspiin hav bn administd togth up ton ya.

Atovastatin ducs total-C, LDL-C and apB in patints with homozygous and htozygous H, nonamilial oms hypcholstolmia and mixd dyslipidmia. Atovastatin alsducs VLDL-C and TG and poducs vaiabl incass in HDL-C and apA-1. Atovastatin ducs total-C, LDL-C, VLDL-C, apB, TG and non-HDL-C and incass HDL-C in patints with isolatd hyptiglycidmia. Atovastatin ducs IDL cholstol (IDL-C) in patints with dysbtalipopotinmia.

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atorlip-f fenofibrate demonstrated a non-significant 11 relative reduction in the primary outcome of coronary heart disease events hazard ratio hr 0.

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Claithomycin : Atovastatin AUC was signiicantly incasd with concomitant administation atovastatin 80 mg with claithomycin (500 mg twic daily) compad tthat atovastatin alon. Tho, in patints taking claithomycin, caution should b usd whn th dos atovastatin xcds 20 mg.

ATOLIP CV (atovastatin and clopidogl) is indicatd in patints whom tatmnt with both atovastatin and clopidogl is appopiat.

In adult patints without clinically vidnt CHD, but with multipl isk actos CHD such as ag, smoking, hyptnsion, low HDL-C, a amily histoy aly CHD, atovastatin is indicatd to.

Atovastatin is a slctiv, comptitiv inhibit3-hydoxy-3-mthylglutayl-conzym A (HMG-CoA) ductas, th at-limiting nzym that convts 3-HMG-CoA tmvalonat, a pcusstols, including cholstol. Cholstol and tiglycids (TG) ciculat in th bloodstam as pat lipopotin complxs. With ultacntiugation, ths complxs spaat inthigh-dnsity lipopotin (HDL), intmdiat-dnsity lipopotin (IDL), low-dnsity lipopotin (LDL) and vy-low-dnsity lipopotin (VLDL) actions. TG and cholstol in th liv a incopoatd intVLDL and lasd intth plasma dlivy tpiphal tissus. LDL is omd om VLDL and is catabolizd pimaily though th high-ainity LDL cpto.

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mild to moderate hemoglobin, hematocrit, and white blood cell decreases have been observed in patients following initiation of atorlip-f therapy.

4 for fenofibrate monotherapy n 188 and atorlip-ez ezetimibe co-administered with fenofibrate n 183 , respectively, adjusted for treatment exposure.

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