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Imuran therapy should not be initiated in patients who may be pregnantor who are likely to become pregnant without careful assessment of risk versus benefitsee Special Warnings and Precautions for UsePregnancy and Lactation

The principal and potentially serious toxic effects of IMURAN are hematologic and gastrointestinalThe risks of secondary infection and malignancy are also significantsee WARNINGSThe frequency and severity of adverse reactions depend on the dose and duration of IMURAN as well as on the patient’s underlying disease or concomitant therapiesThe incidence of hematologic toxicities and neoplasia encountered in groups of renal homograft recipients is significantly higher than that in studies employing IMURAN for rheumatoid arthritisThe relative incidences in clinical studies are summarized below:

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